Selective pressure as an essential force in molecular evolution of myeloid leukemic clones: a view from the window of Fanconi anemia

@article{Lensch1999SelectivePA,
  title={Selective pressure as an essential force in molecular evolution of myeloid leukemic clones: a view from the window of Fanconi anemia},
  author={M Lensch and R. Keaney Rathbun and S W Olson and G Jones and G Bagby},
  journal={Leukemia},
  year={1999},
  volume={13},
  pages={1784-1789}
}
Specific chromosomal deletions are commonly found in bone marrow cells of children with Fanconi anemia (FA) whose disease has evolved to myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Identical deletions are found in adults with MDS/AML with a history of exposure to alkylating agents (secondary MDS/AML). While deleted chromosomal regions likely harbor genes encoding proteins with tumor suppressor (TS) function, such genes have not been identified and the environmental forces by… CONTINUE READING

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