Selective prefrontal serotonin depletion impairs acquisition of a detour-reaching task.

@article{Walker2006SelectivePS,
  title={Selective prefrontal serotonin depletion impairs acquisition of a detour-reaching task.},
  author={Steven C. Walker and Yevheniia Mikheenko and L D Argyle and Trevor W. Robbins and Angela C. Roberts},
  journal={The European journal of neuroscience},
  year={2006},
  volume={23 11},
  pages={
          3119-23
        }
}
We have recently shown that serotonin in the primate orbitofrontal cortex (OFC) contributes to the flexible control of behaviour. 5,7-dihydroxytryptamine-induced 5-HT depletions of OFC impair performance on a serial reversal discrimination task [Clarke et al. (2004)Science, 304, 878-880]. The deficit is characterized by perseverative responding to the previously rewarded stimulus, a deficit similar to that seen following lesions of the intrinsic neurones of the OFC [Dias et al. (1996)Nature… CONTINUE READING

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