Selective postmortem degradation of inducible heat shock protein 70 (hsp70) mRNAs in rat Brain

  title={Selective postmortem degradation of inducible heat shock protein 70 (hsp70) mRNAs in rat Brain},
  author={Sibile Pardue and Anton L. Zimmerman and Marcelle Morrison-Bogorad},
  journal={Cellular and Molecular Neurobiology},
1. Altered mRNA levels in postmortem brain tissue from persons with Alzheimer's disease (AD) or other neurological diseases are usually presumed to be characteristic of the disease state, even though both agonal state (the physiological state immediately premortem) and postmortem interval (PMI) (the time between death and harvesting the tissue) have the potential to affect levels of mRNAs measured in postmortem tissue. Although the possible effect of postmortem interval on mRNA levels has been… CONTINUE READING
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The effects of Alzheimer ' s disease , other dementias , and premortem course on gamyloid precursor protein messenger RNA in frontal cortex

  • N. J. Holbrook, S. G. Carlson, A. M. Choi, J. Fargnoli
  • J . Neurochern .
  • 1994

Heat shock protein ( hsx 70 ) mRNA expression in human brain : Effects of neurodegenerative disease and agonal state

  • P. J. Harrison, A. J. L. Barton, A. W. Procter, D. M. Bowen, R. C. A. Pearson
  • Neuropathol . Appl . Neurobiol .
  • 1993

Pre - and postmortem influences on brain RNA

  • A. J. L. R E F E R E N C E S Barton, R. C. A. Pearson, A. Najlerahim, P. J. Harrison
  • J . Neurochem .
  • 1993

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