Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2.

@article{Kasumu2012SelectivePM,
  title={Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2.},
  author={Adebimpe W Kasumu and Charlotte O Hougaard and F Rode and Thomas Amos Jacobsen and Jean Marc Sabatier and Birgitte Langer Eriksen and Dorte Str\ob{\ae}k and Xia Liang and Polina A Egorova and Dasha Vorontsova and Palle Christophersen and Lars Christian Biilmann R\onn and Ilya B Bezprozvanny},
  journal={Chemistry & biology},
  year={2012},
  volume={19 10},
  pages={1340-53}
}
Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disorder caused by a polyglutamine expansion within the Ataxin-2 (Atxn2) protein. Purkinje cells (PC) of the cerebellum fire irregularly and eventually die in SCA2. We show here that the type 2 small conductance calcium-activated potassium channel (SK2) play a key role in control of normal PC activity. Using cerebellar slices from transgenic SCA2 mice we demonstrate that SK channel modulators restore regular pacemaker activity of SCA2… CONTINUE READING
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