Selective plasma kallikrein inhibitor attenuates acute intestinal inflammation in lewis rat

  title={Selective plasma kallikrein inhibitor attenuates acute intestinal inflammation in lewis rat},
  author={Dr. Antoni Stadnicki and Raul A. Dela Cadena and Ryan Balfour Sartor and BS DianeBender and Charles A. Kettner and Heiko C. Rath and Albert Adam and Dr. Robert W. Colman},
  journal={Digestive Diseases and Sciences},
A specific plasma kallikrein inhibitor, Bz-Pro-Phe-boroArg (P8720), was used to define the relationship between the kallikrein-kinin (K-K) system and acute intestinal inflammation induced by bacterial peptidoglycan-polysaccharide (PG-APS) in Lewis rats. Group I received human serum albumin (HSA) intramurally in the intestine and was treated with HSA. Group II received PG-APS and was treated with P8720. Group III received PG-APS and was treated with HSA. P8720 attenuated the decrease of high… CONTINUE READING


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