Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer.

@article{Yogo2008SelectivePO,
  title={Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer.},
  author={Takatoshi Yogo and Yasuteru Urano and Akiko Mizushima and Hisato Sunahara and Takanari Inoue and Kenzo Hirose and Masamitsu Iino and Kazuya Kikuchi and Tetsuo Suginami-ku Nagano},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 1},
  pages={
          28-32
        }
}
Chromophore-assisted light inactivation is a promising technique to inactivate selected proteins with high spatial and temporal resolution in living cells, but its use has been limited because of the lack of a methodology to prevent nonspecific photodamage in the cell owing to reactive oxygen species generated by the photosensitizer. Here we present a design strategy for photosensitizers with an environment-sensitive off/on switch for singlet oxygen ((1)O(2)) generation, which is switched on by… CONTINUE READING

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