Selective phosphorylation of human DNA methyltransferase by protein kinase C.

Abstract

Human DNA methyltransferase, the enzyme thought to be responsible for the somatic inheritance of patterns of DNA methylation, is an effective substrate for phosphorylation by protein kinase C. This provides a plausible mechanistic link between the action of tumor promoting phorbol esters, which stimulate protein kinase C, and abnormal patterns of DNA methylation often observed in transformed cells.

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@article{DePaoliRoach1986SelectivePO, title={Selective phosphorylation of human DNA methyltransferase by protein kinase C.}, author={Anna A. DePaoli-Roach and Peter J. Roach and Konrad Zucker and Spenser S Smith}, journal={FEBS letters}, year={1986}, volume={197 1-2}, pages={149-53} }