Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

@article{Ferreira1997SelectivePO,
  title={Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.},
  author={Adriana Carolina Marques Ferreira and Qingxian Lu and Lisa Orecchio and Kenneth S. Kosik},
  journal={Molecular and cellular neurosciences},
  year={1997},
  volume={9 3},
  pages={220-34}
}
How senile plaques and neurofibrillary tangles are linked represents a major gap in our understanding of the pathophysiology of Alzheimer's disease. We characterized a hippocampal neuronal culture system in which tau undergoes maturation in vivo; rat neurons maintained in culture for more than 3 weeks replicated the splicing and phosphorylation changes that tau undergoes upon maturation in situ. Using this model system, we induced an Alzheimer-like neuritic dystrophy following the application… CONTINUE READING
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