Selective pharmacologic inhibition of a PASTA kinase increases Listeria monocytogenes susceptibility to β-lactam antibiotics.

@article{Pensinger2014SelectivePI,
  title={Selective pharmacologic inhibition of a PASTA kinase increases Listeria monocytogenes susceptibility to β-lactam antibiotics.},
  author={Daniel A Pensinger and Matthew T Aliota and Adam J. Schaenzer and Kyle M Boldon and Israr-ul H. Ansari and William J. B. Vincent and Benjamin Knight and Michelle L. Reniere and Rob Striker and John-Demian Sauer},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 8},
  pages={4486-94}
}
While β-lactam antibiotics are a critical part of the antimicrobial arsenal, they are frequently compromised by various resistance mechanisms, including changes in penicillin binding proteins of the bacterial cell wall. Genetic deletion of the penicillin binding protein and serine/threonine kinase-associated protein (PASTA) kinase in methicillin-resistant Staphylococcus aureus (MRSA) has been shown to restore β-lactam susceptibility. However, the mechanism remains unclear, and whether… CONTINUE READING

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