Selective p38α mitogen-activated protein kinase inhibitor attenuates lung inflammation and fibrosis in IL-13 transgenic mouse model of asthma

@inproceedings{Ma2008SelectivePM,
  title={Selective p38α mitogen-activated protein kinase inhibitor attenuates lung inflammation and fibrosis in IL-13 transgenic mouse model of asthma},
  author={Jennifer Ma and Satyanarayana Medicherla and Irene Kerr and Ruban Mangadu and Andrew A. Protter and Linda Slanec Higgins},
  booktitle={Journal of asthma and allergy},
  year={2008}
}
p38 Mitogen-activated protein kinase (MAPK) plays a critical role in the activation of inflammatory cells. We investigated the anti-inflammatory effects of a p38α-selective MAPK inhibitor (SD-282) in a mouse transgenic (CC10:IL-13) asthma model. The CC-10-driven over-expression of IL-13 in the mouse lung/airway has been shown to result in a remarkable… CONTINUE READING