Selective p38α MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction

@article{Bruchas2011SelectivePM,
  title={Selective p38α MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction},
  author={Michael R Bruchas and Abigail G. Schindler and Haripriya Shankar and Daniel I. Messinger and Mayumi Miyatake and Benjamin B. Land and Julia Cristine Lemos and Catherine E. Hagan and John F. Neumaier and Albert Villalta Quintana and Richard D Palmiter and Charles Chavkin},
  journal={Neuron},
  year={2011},
  volume={71},
  pages={498-511}
}
Maladaptive responses to stress adversely affect human behavior, yet the signaling mechanisms underlying stress-responsive behaviors remain poorly understood. Using a conditional gene knockout approach, the α isoform of p38 mitogen-activated protein kinase (MAPK) was selectively inactivated by AAV1-Cre-recombinase infection in specific brain regions or by promoter-driven excision of p38α MAPK in serotonergic neurons (by Slc6a4-Cre or ePet1-Cre) or astrocytes (by Gfap-CreERT2). Social defeat… CONTINUE READING
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