Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.

@article{Lechner2011SelectiveOO,
  title={Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.},
  author={Anna Lechner and Alessandra S Eust{\'a}quio and Tobias A. M. Gulder and M. R. Hafner and Bradley S Moore},
  journal={Chemistry & biology},
  year={2011},
  volume={18 12},
  pages={1527-36}
}
The chlorinated natural product salinosporamide A is a potent 20S proteasome inhibitor currently in clinical trials as an anticancer agent. To deepen our understanding of salinosporamide biosynthesis, we investigated the function of a LuxR-type pathway-specific regulatory gene, salR2, and observed a selective effect on the production of salinosporamide A over its less active aliphatic analogs. SalR2 specifically activates genes involved in the biosynthesis of the halogenated precursor… CONTINUE READING