Selective noradrenergic vulnerability in α-synuclein transgenic mice.

  title={Selective noradrenergic vulnerability in α-synuclein transgenic mice.},
  author={Evangelos Sotiriou and Demetrios K. Vassilatis and Miquel Vila and Leonidas Stefanis},
  journal={Neurobiology of aging},
  volume={31 12},
Classical pathological signs of Parkinson's disease (PD) include loss of dopaminergic neurons in substantia nigra (SN) and noradrenergic neurons in locus coeruleus (LC), and deposition of Lewy bodies rich in the presynaptic protein alpha-synuclein (ASYN). Mammalian genetic models based on ASYN overexpression, however, have generally not reproduced the profound dopaminergic deficit of PD and do not display classical PD phenotypes. In the current study we examined these catecholaminergic systems… CONTINUE READING