Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells.

@article{Jain2004SelectiveNA,
  title={Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells.},
  author={Anshu K Jain and Scott M. Moore and Kiyoshi Yamaguchi and Thomas E. Eling and Seung Joon Baek},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={311 3},
  pages={
          885-91
        }
}
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their anti-inflammatory effects and have been shown to have chemopreventive effects as well. NSAIDs inhibit cyclooxygenase (COX) activity to exert their anti-inflammatory effects, but it is not clear whether their antitumorigenic ability is through COX inhibition. Using subtractive hybridization, we previously identified a novel member of the transforming growth factor-beta superfamily that has antitumorigenic activity from… CONTINUE READING

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