Selective neurotoxic action of capsaicin on glomerular C-type terminals in rat substantia gelatinosa.

Abstract

This study demonstrates that capsaicin exerts a selective neurotoxic action to induce degeneration of glomerular C-type nerve terminals in adult rats. Since the C terminals may be essential components of the circuitry for modulation of pain, it is suggested that capsaicin induced analgesia is the result of this neurotoxic action. 

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