Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms.

@article{Burns2011SelectiveMI,
  title={Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms.},
  author={Katherine A. Burns and Yin Li and Yukitomo Arao and Robert M. Petrovich and Kenneth S. Korach},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 14},
  pages={12640-9}
}
The three main mechanisms of ERα action are: 1) nuclear, genomic, direct DNA binding, 2) nuclear, genomic, "tethered"-mediated, protein-protein interactions, and 3) non-nuclear, non-genomic, rapid action responses. Reports suggest the D-domain or hinge region of ERα plays an important role in mechanisms 1 and 2 above. Studies demonstrating the functionality of the ERα hinge region have resected the full D-domain; therefore, site directed mutations were made to attribute precise sequence… CONTINUE READING

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