Selective modulation of cell adhesion molecules on lymphocytes by bromelain protease 5.

@article{Kleef1996SelectiveMO,
  title={Selective modulation of cell adhesion molecules on lymphocytes by bromelain protease 5.},
  author={Regina G. D. M. van Kleef and Thomas M. Delohery and Dana Howard Bovbjerg},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  year={1996},
  volume={64 6},
  pages={339-46}
}
Human peripheral blood mononuclear cells from healthy donors were treated ex vivo with the proteolytic enzyme bromelain and studied by flow cytometry. Bromelain-treated lymphocytes exhibited 60-90% reduced cell surface staining for CD44 and CD62-L molecules. While the staining for molecules CD16, CD56 and CD49d was unaffected, a moderate increase (10-40%) in expression of the beta(2)-integrins CD11a-c was seen. This selective modulation of cell adhesion molecules (CAM) was seen on T cells and… CONTINUE READING

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