Selective modulation of NMDA responses by reduction and oxidation

@article{Aizenman1989SelectiveMO,
  title={Selective modulation of NMDA responses by reduction and oxidation},
  author={E. Aizenman and S. Lipton and R. Loring},
  journal={Neuron},
  year={1989},
  volume={2},
  pages={1257-1263}
}
Electrophysiological responses to the glutamate analog N-methyl-D-aspartate (NMDA) measured in three different central neuronal preparations are subject to a novel modulatory mechanism: they are substantially potentiated after exposure to the disulfide reducing agent dithiothreitol, while oxidation with 5-5-dithiobis-2-nitrobenzoic acid decreases the magnitude of the response. Modification of the NMDA response by either oxidation or reduction does not appear to affect the pharmacological… Expand
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