Selective mitochondrial Ca 2 + uptake deficit in disease endstage vulnerable motoneurons of the SOD 1 G 93 A mouse model of amyotrophic lateral sclerosis

@inproceedings{Fuchs2013SelectiveMC,
  title={Selective mitochondrial Ca 2 + uptake deficit in disease endstage vulnerable motoneurons of the SOD 1 G 93 A mouse model of amyotrophic lateral sclerosis},
  author={Andrea Fuchs and Sylvie Kutterer and Tobias M{\"u}hling and Johanna Duda and Burkhard Sch{\"u}tz and Birgit Liss and Bernhard U. Keller and Jochen Roeper},
  year={2013}
}
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that targets some somatic motoneuron populations, while others, e.g. those of the oculomotor system, are spared. The pathophysiological basis of this pattern of differential vulnerability, which is preserved in a transgenic mouse model of amyotrophic lateral sclerosis (SOD1), and the mechanism of neurodegeneration in general are unknown. Hyperexcitability and calcium dysregulation have been proposed by others on the basis… CONTINUE READING
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