• Corpus ID: 34990600

Selective metabolic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea upon de novo purine biosynthesis.

@article{Groth1971SelectiveME,
  title={Selective metabolic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea upon de novo purine biosynthesis.},
  author={Donald P. Groth and J. D'angelo and William R. Vogler and Elizabeth S. Mingioli and B. Betz},
  journal={Cancer research},
  year={1971},
  volume={31 3},
  pages={
          332-6
        }
}
The rate of incorporation of formate-14C into the nucleic acid purines of leukemic cells was stimulated by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). This observation indicated that BCNU had an effect on de novo purine biosynthesis, affecting a certain reaction(s) involved with the insertion of either the C-2 or C-8 position of the purine ring. Studies with aminoimidazolecarboxamide riboside showed no direct effect of BCNU on the insertion of formate-14C into the C-2 position. The rate of… 

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