Selective loss of striatal preprotachykinin neurons in a phenocopy of Huntington's disease.

@article{Richfield2002SelectiveLO,
  title={Selective loss of striatal preprotachykinin neurons in a phenocopy of Huntington's disease.},
  author={Eric K. Richfield and J. Vonsattel and Marcy E. MacDonald and Zhiqiang Sun and Yun-Ping Deng and Anton Reiner},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2002},
  volume={17 2},
  pages={327-32}
}
Phenocopies of Huntington's disease (HD) are individuals with a family history, clinical symptoms, and occasionally pathological evidence of HD but without an expanded CAG repeat within the HD gene. We report on an HD phenocopy with selective loss of preprotachykinin (PPT) neurons, dysfunction of surviving PPT neurons, preservation of preproenkephalin (PPE) neurons within the striatum, and greater loss of immunohistochemical staining for substance P in terminals of striatal neurons projecting… CONTINUE READING