Selective loss of hippocampal granule cells following adrenalectomy: implications for spatial memory.

@article{Conrad1993SelectiveLO,
  title={Selective loss of hippocampal granule cells following adrenalectomy: implications for spatial memory.},
  author={Cheryl D. Conrad and Edward J. Roy},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1993},
  volume={13 6},
  pages={2582-90}
}
We examined the effects of long-term adrenalectomy (ADX) on hippocampal anatomy and behavioral learning in two spatial memory tasks. We assessed damage throughout the hippocampus by stereological analysis of the dentate gyrus and Ammon's horn. Rats were ADX or sham operated, and then tested in the Morris water maze 12 weeks after surgery, followed by testing on an eight-arm, alternating-baited radial maze at 22 weeks postsurgery. Animals were killed 7 1/2 months after surgery. ADX rats had… CONTINUE READING

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