Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis.

Abstract

The pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) is unknown, but defects in synaptosomal high-affinity glutamate transport have been observed. In experimental models, chronic loss of glutamate transport can produce a loss of motor neurons and, therefore, could contribute to the disease. With the recent cloning of three glutamate transporters… (More)

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@article{Rothstein1995SelectiveLO, title={Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis.}, author={Jeffrey D Rothstein and Marieke van Kammen and Allan I. Levey and Lee Martin and Ralph W. Kuncl}, journal={Annals of neurology}, year={1995}, volume={38 1}, pages={73-84} }