Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy.

@article{Zhang2006SelectiveLO,
  title={Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy.},
  author={Wei Zhang and Thomas Anger and Jialin Su and Jianming Hao and Xiaomei Xu and Ming Zhu and Agnieszka A Gach and Lei Cui and Ronglih Liao and Ulrike Mende},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 9},
  pages={5811-20}
}
Alterations in cardiac G protein-mediated signaling, most prominently G(q/11) signaling, are centrally involved in hypertrophy and heart failure development. Several RGS proteins that can act as negative regulators of G protein signaling are expressed in the heart, but their functional roles are still poorly understood. RGS expression changes have been described in hypertrophic and failing hearts. In this study, we report a marked decrease in RGS2 (but not other major cardiac RGS proteins (RGS3… CONTINUE READING
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