Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia.

@article{Schmauss1993SelectiveLO,
  title={Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia.},
  author={C Schmauss and Vahram Haroutunian and Kenneth L. Davis and Maximillian Davidson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 19},
  pages={8942-6}
}
The expression of dopamine D3-subtype-receptor mRNA was analyzed in defined anatomic regions of brain obtained postmortem from patients with chronic schizophrenia and from controls. The specific amplification of D3-encoding cDNA by PCR allowed the identification of D3 mRNA expression in a wide variety of anatomic regions in both control brains and brains obtained from schizophrenic patients. However, in the parietal cortex (Brodmann areas 1, 2, 3, and 5) and motor cortex (Brodmann area 4), a… CONTINUE READING

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