Selective loss of dentate hilar interneurons contributes to reduced synaptic inhibition of granule cells in an electrical stimulation-based animal model of temporal lobe epilepsy.

@article{Sun2007SelectiveLO,
  title={Selective loss of dentate hilar interneurons contributes to reduced synaptic inhibition of granule cells in an electrical stimulation-based animal model of temporal lobe epilepsy.},
  author={Chengsan Sun and Zakaria Mtchedlishvili and Edward H. Bertram and Alev Erisir and Jaideep Kapur},
  journal={The Journal of comparative neurology},
  year={2007},
  volume={500 5},
  pages={876-93}
}
Neuropeptide-containing hippocampal interneurons and dentate granule cell inhibition were investigated at different periods following electrical stimulation-induced, self-sustaining status epilepticus (SE) in rats. Immunohistochemistry for somatostatin (SOM), neuropeptide Y (NPY), parvalbumin (PV), cholecystokinin (CCK), and Fluoro-Jade B was performed on sections from hippocampus contralateral to the stimulated side and studied by confocal laser scanning microscopy. Compared to paired age… CONTINUE READING

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