Selective localization of cardiac SCN5A sodium channels in limbic regions of rat brain

Abstract

Voltage-dependent sodium channels have a critical role in membrane electrogenesis and repetitive firing in excitable cells. Members of this gene superfamily exhibit diffuse, tissue-specific expression in nervous, muscle and cardiac tissues. Tetrodotoxin (TTX) sensitivity and resistance to zinc blockade were thought to distinguish brain from heart sodium… (More)
DOI: 10.1038/10147

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