Selective leukocyte apheresis for the treatment of inflammatory bowel disease.

@article{Abreu2007SelectiveLA,
  title={Selective leukocyte apheresis for the treatment of inflammatory bowel disease.},
  author={Maria T. Abreu and Scott Eric Plevy and Bruce E. Sands and Robert Weinstein},
  journal={Journal of clinical gastroenterology},
  year={2007},
  volume={41 10},
  pages={
          874-88
        }
}
The etiology of inflammatory bowel disease (IBD) is not completely understood, thus current therapies have been empirical and directed at treating symptoms rather than addressing the cause. In IBD, the overexpression of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, leads to a persistent intestinal inflammatory response that damages the intestinal mucosa. Recent advances in pharmacologic therapies that target specific cytokines, chemokines, and… 
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