Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility.

@article{Cabrera2006SelectiveLO,
  title={Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility.},
  author={S. C. Motta Cabrera and Candice M. Chavez and Sean R Corley and Michael R Kitto and Allen E. Butt},
  journal={Behavioral neuroscience},
  year={2006},
  volume={120 2},
  pages={298-306}
}
The authors tested the hypothesis that the cholinergic nucleus basalis magnocellularis (NBM) is involved in solving problems requiring cognitive flexibility. Rats with 192 IgG-saporin lesions of the NBM were assessed for perseveration (i.e., cognitive inflexibility) in the serial reversal of an operant discrimination and during subsequent extinction testing. It was hypothesized that the NBM lesion and control groups would not differ in the acquisition of the initial, simple discrimination… CONTINUE READING

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