Selective lesions of the dorsomedial striatum impair serial spatial reversal learning in rats

@inproceedings{Castane2010SelectiveLO,
  title={Selective lesions of the dorsomedial striatum impair serial spatial reversal learning in rats},
  author={A. Castane and David E. H. Theobald and Trevor W. Robbins},
  booktitle={Behavioural Brain Research},
  year={2010}
}
Impairments in reversal learning have been attributed to orbitofrontal cortex (OFC) dysfunction in many species. However, the role of subcortical areas interconnected with the OFC such as the striatum remains poorly understood. This study directly evaluated the contribution of core and shell sub-regions of the nucleus accumbens (NAc), dorsomedial (DMS) and dorsolateral (DLS) striatum to reversal learning of an instrumental two-lever spatial discrimination task in rats. Selective NAc core, DMS… CONTINUE READING

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