Selective lesions of acinar pancreatic cells in rats poisoned with abrin. A morphological and biochemical study.

@article{Barbieri1979SelectiveLO,
  title={Selective lesions of acinar pancreatic cells in rats poisoned with abrin. A morphological and biochemical study.},
  author={Luigi Barbieri and Anna Gasperi-Campani and Massimo Derenzini and Christine Margaret Betts and Fiorenzo Stirpe},
  journal={Virchows Archiv. B, Cell pathology including molecular pathology},
  year={1979},
  volume={30 1},
  pages={15-24}
}
Rats poisoned with abrin (2.5 micrograms/100 g body weight) died within 36 h with severe necrosis of acinar pancreatic cells. Incorporation in vivo of labelled amino acids into pancreatic protein was greatly impaired 6 h after poisoning. Microsomes isolated from the pancreas of poisoned rats at 6 h had a reduced capacity for protein synthesis in vitro. Incorporation in vivo of orotic acid into pancreatic RNA was decreased 12 h after poisoning.