Selective lead compounds against kinetoplastid tubulin.

  title={Selective lead compounds against kinetoplastid tubulin.},
  author={Rachel E. Morgan and Karl A. Werbovetz},
  journal={Advances in experimental medicine and biology},
Kinetoplastid parasites are responsible for the potentially fatal diseases leishmaniasis, African sleeping sickness and Chagas disease. The current treatments for these diseases are far from ideal and new compounds are needed as antiparasitic drug candidates. Tubulin is the accepted target for treatments against cancer and helminths, suggesting that kinetoplastid tubulin is also a suitable target for antiprotozoal compounds. Selective lead compounds against kinetoplastid tubulin have been… CONTINUE READING

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