Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity.

@article{Bonatti2014SelectiveLS,
  title={Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity.},
  author={Rodolfo Bonatti and Ana Fl{\'a}via Garcia Silva and J{\'u}lio Am{\'e}rico Pereira Batatinha and Lucas Faraco Sobrado and Ananda Dianni Machado and Bruno Butturi Varone and Bruce D. Nearing and Luiz Belardinelli and Richard L Verrier},
  journal={Heart rhythm},
  year={2014},
  volume={11 10},
  pages={1827-35}
}
BACKGROUND Ischemic heart disease is associated with dual risk for atrial and ventricular arrhythmias. OBJECTIVE We examined whether selectively targeting late sodium channel current (INa) with GS-458967 (hereafter GS967) can reduce cardiac electrical instability and compared its effects to a clinically relevant dose of flecainide. METHODS Electrode catheters were positioned on the left atrial appendage and left ventricle of anesthetized pigs to monitor repolarization alternans and… CONTINUE READING
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