Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer.

@article{KizakaKondoh2009SelectiveKO,
  title={Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer.},
  author={Shinae Kizaka-Kondoh and Satoshi Itasaka and Lihua Zeng and Shotaro Tanaka and Tao Zhao and Yumi Takahashi and Keiko Shibuya and Kiichi Hirota and Gregg L Semenza and Masahiro Hiraoka},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 10},
  pages={3433-41}
}
PURPOSE Pancreatic cancer is characterized by intratumoral hypoxia, early and aggressive local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major transcriptional activator of hypoxia-responsive genes and intratumoral hypoxia is associated with increased risk of metastasis. However, the behavior of the cells having HIF-1 activity during the malignant progression in pancreatic cancer has not been tested. EXPERIMENTAL DESIGN We orthotopically transplanted… CONTINUE READING

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