Selective killing of Paneth cells by intravenous administration of dithizone in rats.

@article{Sawada1991SelectiveKO,
  title={Selective killing of Paneth cells by intravenous administration of dithizone in rats.},
  author={Michio Sawada and Kiyoshi Takahashi and Shojiro Sawada and Osamu Midorikawa},
  journal={International journal of experimental pathology},
  year={1991},
  volume={72 4},
  pages={407-21}
}
Paneth cells are zinc-containing cells widely distributed in Lieberkühn's crypts of intestine in a variety of species. We found that rapid selective killing of Paneth cells took place after the intravenous (i.v.) injection of diphenylthiocarbazone (dithizone), a chelator forming a zinc dithizonate complex, in the rat. As soon as 5 min after the i.v. injection of dithizone, degeneration of Paneth cells occurred. At this stage, zinc dithizonate complexes were observed as purple-red granules in… CONTINUE READING