Selective isolation of G-quadruplexes by affinity chromatography.


G-quadruplex (G4) is a characteristic secondary structure of nucleic acids containing repetitive tandem guanines. G4-forming sequences are found prevalent in the human genome by bioinformatics analysis. Accumulating evidence has suggested that G4s are involved in many biological processes. Selective isolation of G4s would be an effective tool in the study… (More)
DOI: 10.1016/j.chroma.2012.02.026


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