Selective iron deposition in pancreatic islet B cells of transfusional iron‐overloaded autopsy cases

@article{Lu1994SelectiveID,
  title={Selective iron deposition in pancreatic islet B cells of transfusional iron‐overloaded autopsy cases},
  author={Jian‐ping Lu and Keiki Hayashi},
  journal={Pathology International},
  year={1994},
  volume={44}
}
Pancreatic islets of 36 autopsy cases with transfusional iron‐overload were examined. Immunohistochemical and histo‐chemical stainings were used to clarify the relationship between blood transfusion and iron deposition in the islet. Disease of the lymphohemopoietic system (leukemia, lymphoma, aplastic anemia) or liver (carcinoma and/or cirrhosis) accounted for 86.1% of the patients’main diagnosis. Sixteen of them had slight hemosiderin deposition (Group 1), twenty cases had severe hemosiderin… 
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Iron-elimination therapy was initiated by chelation or phlebotomy, and the birds’ diet was changed to low-iron content pellets, showing a decreased demand for extrinsic insulin.
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