Selective iron deposition in pancreatic islet B cells of transfusional iron‐overloaded autopsy cases

  title={Selective iron deposition in pancreatic islet B cells of transfusional iron‐overloaded autopsy cases},
  author={Jian‐ping Lu and Keiki Hayashi},
  journal={Pathology International},
Pancreatic islets of 36 autopsy cases with transfusional iron‐overload were examined. Immunohistochemical and histo‐chemical stainings were used to clarify the relationship between blood transfusion and iron deposition in the islet. Disease of the lymphohemopoietic system (leukemia, lymphoma, aplastic anemia) or liver (carcinoma and/or cirrhosis) accounted for 86.1% of the patients’main diagnosis. Sixteen of them had slight hemosiderin deposition (Group 1), twenty cases had severe hemosiderin… 
Immunohistochemical findings in the pancreatic islets of a patient with transfusional iron overload and diabetes: case report.
An immunohistochemical analysis to study an autopsy case of aplastic anemia and diabetic hemochromatosis caused by frequent blood transfusions found significantly lower levels of immunoreactivity with both insulin antibodies and proinsulin antibodies, but not with glucagon antibodies, was observed.
Transferrin receptor distribution and iron deposition in the hepatic fobufe of iron‐overloaded rats
In iron‐overloaded rats, the iron deposition was severe in zone 1 and mild in zone 3 hepatocytes, suggesting that uptake of iron into hepatocytes in vivo is regulated and mediated by TfR and Tf.
Toward resolving the unsettled role of iron chelation therapy in myelodysplastic syndromes
Although suggested by retrospective analyses, the lack of clear prospective data of the beneficial effects of iron chelation on morbidity and survival, the role ofIron chelation therapy in MDS patients remains controversial.
Multi-Organ Iron Overload in an African-American Man with ALAS2 R452S and SLC40A1 R561G
ALAS2 R452S largely explains this patient’s microcytic anemia and multi-organ iron overload and dysfunction and Acquired factors, especially cocaine use and hepatitis C, may have contributed to his clinical phenotype.
A pilot MRI study of organ specific hemosiderosis and functional correlation in Chinese patients with myelodysplasia and aplastic anemia with raised ferritin levels
Significant correlation was found between cardiac T2/T2* MRI assessment, ejection fraction and ferritin levels, and there was a high incidence subclinical pancreatic abnormality that was related to liver MRI T2* readings.
Diabetes mellitus concurrent with hepatic haemosiderosis in two macaws (Ara severa, Ara militaris)
Iron-elimination therapy was initiated by chelation or phlebotomy, and the birds’ diet was changed to low-iron content pellets, showing a decreased demand for extrinsic insulin.
Quantification of pancreatic iron overload and fat infiltration and their correlation with glucose disturbance in pediatric thalassemia major patients.
Pediatric TM patients can have homogeneous iron siderosis and heterogeneous fat infiltration in the pancreas as measured by gradient-echo imaging, both of which are risk factors for diabetes.
Iron chelation therapy in myelodysplastic syndromes: where do we stand?
The authors summarize the current knowledge regarding IO in MDS and the role of ICT and suggest that iron chelation therapy (ICT) remains a very controversial aspect in the management of MDS.


Clinical consequences of acquired transfusional iron overload in adults.
It is concluded that widespread subclinical organ dysfunction can result from transfusional iron overload developing in adulthood, and the pattern of organ involvement resembles that encountered in idiopathic hemochromatosis.
Hemosiderin deposition in the pancreas.
  • K. Suda
  • Medicine
    Archives of pathology & laboratory medicine
  • 1985
In patients with primary hemochromatosis and in patients with aplastic anemia who had received blood transfusions over a long period, micronodular formation in the exocrine pancreas was one of the characteristic findings.
Parenchymal versus reticuloendothelial iron overload in the liver: distinction with MR imaging.
Parenchymal iron deposition occurs in hemochromatosis, while iron is deposited in reticuloendothelial (RE) cells after blood transfusions or rhabdomyolysis. Magnetic resonance images of patients with
Transferrin Receptors and Selective Iron Deposition in Pancreatic B Cells of Iron‐overloaded Rats
Iron overload was produced in Wistar rats by repeated intraperitoneal injections of ferric nitrilotriacetate (Fe3+‐NTA) for one to six months and findings suggest that iron uptake by islet cells in vivo is regulated and mediated by TfR.
Generalized siderosis with fibrosis of liver and pancreas in Cooley's (Mediterranean) anemia; with observations on the pathogenesis of the siderosis and fibrosis.
There was pronounced clinical improvement and higher hemoglobin levels were maintained than preoperatively despite less frequent administration of blood despite greater frequency of transfusions, and during this period the spleen had increased greatly in size and extended into the pelvis.
Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate. A model of experimental hemochromatosis.
Repeated blood withdrawals from ferric-nitrilotriacetate-treated animals resulted in disappearance of hypergycmia, glycosuria, ketonemia, and ketonuria; disappearance of iron from the liver and pancreas; and restoration of islet beta granules to the control level.
Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis.
The increased iron absorption in hereditary hemochromatosis is mediated primarily by an increase in the rate constant for transfer of mucosal iron to the plasma.
Pancreatic Islets after Repeated Injection of Fe3+‐NTA An Ultrastructural Study of Diabetic Rats
Repeated venesection therapy of rats injected with Fe3+‐NTA for 120 days resulted in an increase of morphologically normal B cells with a smaller number of necrotizing cells, accompanied by recovery from diabetic symptoms, and the toxic effect of injected iron on B cells was clarified.
Iron release from haemosiderin and production of iron-catalysed hydroxyl radicals in vitro.
Findings suggested that, under physiological conditions, haemosiderin was not an effective iron donor and was almost not involved in radical production, but under acidic conditions it could possibly be an Iron donor and is thought to be implicated inradical production and tissue damage in iron-overloaded conditions.
PAP was heterogeneous on electrophoresis, homogeneous on sedimentation, diffusion and electron microscopy and consisted of pentagons with diameters of 205 Å, with the unexpected ratio of PO to anti-PO presumed to be due to stabilization by the pentagonal shape.