Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy.

@article{Quader2014SelectiveID,
  title={Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy.},
  author={Sabina Quader and Horacio Cabral and Yuki Mochida and Tomohiro Ishii and Xue-ying Liu and Kazuko Toh and Hiroaki Kinoh and Yuka Miura and Nobuhiko Nishiyama and Kazunori Kataoka},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={188},
  pages={
          67-77
        }
}
The ubiquitin-proteasome system is central in the regulation of cellular proteins controlling cell cycle progression and apoptosis, drawing much interest for developing effective targeted cancer therapies. Herein, we developed a novel pH-responsive polymeric-micelle-based carrier system to effectively deliver the proteasome inhibitor MG132 into cancer cells. MG132 is covalently bound to the block copolymer composed of polyethylene glycol (PEG) and polyaspartate through an acid-labile hydrazone… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Hydrazone linkages in pH responsive drug delivery systems.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2017
VIEW 7 EXCERPTS
CITES METHODS & BACKGROUND