Selective intracellular degradation of fibrinogen and its reversal in cultured hepatocytes.

@article{Grieninger1984SelectiveID,
  title={Selective intracellular degradation of fibrinogen and its reversal in cultured hepatocytes.},
  author={Gerd E. Grieninger and P W Plant and Mary Ann Chiasson},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 23},
  pages={14973-8}
}
Primary monolayer cultures of chick embryo hepatocytes were employed in pulse-chase experiments to examine plasma protein synthesis and secretion. The fates of [35S]methionine-labeled fibrinogen and transferrin were monitored in cell extracts and in spent culture media. It was found that hepatocytes, which were maintained in the absence of added hormones or… CONTINUE READING