Selective intra-arterial infusion of high-dose cisplatin in patients with advanced head and neck cancer results in high tumor platinum concentrations and cisplatin-DNA adduct formation

@article{Los2004SelectiveII,
  title={Selective intra-arterial infusion of high-dose cisplatin in patients with advanced head and neck cancer results in high tumor platinum concentrations and cisplatin-DNA adduct formation},
  author={Gerrit Los and Frank A. Blommaert and R Barton and Dennis D. Heath and L. den Engelse and Catherine Hanchett and Daniel Vicario and Robert A. Weisman and K. Thomas Robbins and Stephen B. Howell},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={37},
  pages={150-154}
}
A group of 23 patients with advanced head and neck cancer were treated with highly selective intra-arterial (IA) cisplatin 150 mg/m2 delivered rapidly through microcatheters. The systemic effects of cisplatin were neutralized by concurrent administration of sodium thiosulfate. Two-to-threefold higher tumor platinum contents were detected in tumor biopsies after selective IA cisplatin administration compared to historicol controls (treated with 100 mg/m2 IA). Cisplatin-induced DNA modification… Expand
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