Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway.

@article{Louhivuori2010SelectiveIW,
  title={Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway.},
  author={Lauri M Louhivuori and Linda C. Jansson and Tommy Nordstr{\"o}m and Genevi{\`e}ve Bart and Johnny N{\"a}sman and Karl E {\AA}kerman},
  journal={Cell calcium},
  year={2010},
  volume={48 2-3},
  pages={114-23}
}
TRPC channels play significant roles in the regulation of neuronal plasticity and development. The mechanism by which these nonselective cation channels exert their trophic actions appears to involve entry of Ca(2+) into the cells. Using a neuronal cell model (differentiated human IMR32 neuroblastoma cells), we demonstrate a central role for sodium entry via TRPC3/6 channels in receptor-mediated increases in intracellular calcium. These Na(+)-dependent Ca(2+) influxes, which were observed in a… CONTINUE READING

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