Selective interference of ACTH4–10 with discriminative responding based on the narcotic cue

@article{Colpaert1978SelectiveIO,
  title={Selective interference of ACTH4–10 with discriminative responding based on the narcotic cue},
  author={F. C. Colpaert and Carlos J. E. Niemegeers and Paul A. J. Janssen and Jan M. van Ree and David de Wied},
  journal={Psychoneuroendocrinology},
  year={1978},
  volume={3},
  pages={203-210}
}
Abstract (1) Using a two-lever, food-rewarded, discrete-trial operant procedure, rats were trained to discriminate 0.04 mg/kg fentanyl from saline. (2) In rats so trained, the peptide fragment 4–10 of adrenocorticotrophic hormone (ACTH 4–10 ) induces transient responding appropriate to the saline condition after fentanyl injection (omission errors). (3) The effect is selective as the induction of omission errors is not accompanied by an increased incidence of commission errors. (4) ACTH 4–10… Expand
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  • Pharmacology Biochemistry and Behavior
  • 1978
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The data indicate that a narcotic action which indirectly increases dopaminergic activity in the brain accounts for a significant, though not critical, component of the discriminative stimulus complex which constitutes the narcotic cue. Expand
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TLDR
It is confirmed that N-terminal fragments of ACTH have an affinity for rat brain opiate receptors in vitro and the structure-activity relationship for these two parameters is comparable to that observed for the same peptides on the induction of excessive grooming. Expand
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The purpose of the present review is to analyze the available literature data on stimulus control by narcotic analgesic drugs, and to discuss some of the conclusions reached thus far. Expand
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