Selective interference of ACTH4–10 with discriminative responding based on the narcotic cue

  title={Selective interference of ACTH4–10 with discriminative responding based on the narcotic cue},
  author={F. C. Colpaert and Carlos J. E. Niemegeers and Paul A. J. Janssen and Jan M. van Ree and David de Wied},
Abstract (1) Using a two-lever, food-rewarded, discrete-trial operant procedure, rats were trained to discriminate 0.04 mg/kg fentanyl from saline. (2) In rats so trained, the peptide fragment 4–10 of adrenocorticotrophic hormone (ACTH 4–10 ) induces transient responding appropriate to the saline condition after fentanyl injection (omission errors). (3) The effect is selective as the induction of omission errors is not accompanied by an increased incidence of commission errors. (4) ACTH 4–10… Expand
12 Citations
Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats
The selective effect on primary learning and on the consolidation and restoration of memory and the presence of only antiamnestic properties suggests different mechanisms of action of these agents. Expand
ACTH 1–17 and short-term memory, anxiety, heart rate, blood pressure
If confirmed by other studies, the short-term memory effect of ACTH 1–17 at 5 min after i.v. could suggest a central action of the peptide, and confirm the role of HPA axis as a modulator of performance and emotional arousal during acute environmental changes. Expand
Reinforcing stimulus properties of drugs
The reinforcing efficacy of psychoactive drugs can reliably be studied in experimental animals by using procedures for drug self-administration. This property of drugs is used to predictExpand
Discriminative stimulus properties of narcotic analgesic drugs
  • F. Colpaert
  • Medicine
  • Pharmacology Biochemistry and Behavior
  • 1978
Evidence that narcotics can act as a discriminative stimulus, and that this cue is an exclusive, complexly composed, and centrally originating property of narcotics, is discussed. Expand
Conditioned taste aversion induced by self-administered drugs: Paradox revisited
  • T. Hunt, Z. Amit
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
  • 1987
It is argued that the CTA literature contains evidence of the existence of two qualitatively distinct types of CTA, one which is mediated by emetic agents and the other induced by SA drugs, and the neural mechanisms underlying both the positive and aversive properties of SA drugs are the same and at the same time different. Expand
Effects of anloxone on Pavlovian conditioning of eyeblink and heart rate responses in rabbits.
Abstract Albino rabbits were subjected to aversive Pavlovian conditioning and extinction of eyeblink and heart rate responses. Naloxone administration had no effect on acquisition of the eyeblinkExpand
Neurohypophysial hormones and addiction
A common denominator for the occurrence of abuse with various psychoactive drugs is their reinforcing property. This can reliably be studied in experimental animals by using procedures for drugExpand
ACTH potentiates morphine-induced conditioned taste aversion
The treatment of rats with intraperitoneal injections of ACTH resulted in a potentiation of a subthreshold dose of morphine to elicit a conditioned taste aversion. Expand
Neural mechanisms of drug stimuli: experimental approaches.
Some of the most important contributions of drug discrimination methodology may arise in the rapidly emerging area of peptide neuropharmacology, where attention is starting to be focused on endogenous neuropeptides, their discriminative stimulus properties and potential role in modulating discriminate effects of drugs. Expand
Brain Peptides and Psychoactive Drug Effects
A peptide is a small protein made up of two or more amino acids linked by peptide bonds. The pituitary gland in particular produces a number of peptide molecules (i.e., hormones) which play aExpand


Discriminative stimulus properties of fentanyl and morphine: Tolerance and dependence
It was found that the ED50 values of both compounds for generalization with the narcotic discriminative stimulus complex, did not change over a 4-month period. Expand
Fentanyl and apomorphine: Asymmetrical generalization of discriminative stimulus properties
The data indicate that a narcotic action which indirectly increases dopaminergic activity in the brain accounts for a significant, though not critical, component of the discriminative stimulus complex which constitutes the narcotic cue. Expand
Long Term and Short Term Effects on Retention of a Conditioned Avoidance Response in Rats by Treatment with Long Acting Pitressin and α-MSH
ATTENTION has recently been focused on the effect of peptides on conditioned avoidance behaviour. It has been shown that adrenocorticotrophic hormone (ACTH) administered during avoidance learningExpand
Effect of ACTH 4–10 on copulatory behavior and on the response in a test for socio-sexual motivation in the female rat
Abstract Female copulatory behavior and the urge of a female rat to seek contact with a sexually active male was studied after treatment with the peptide ACTH 4–10. No effects of this peptide wereExpand
Investigations on drug produced and subjectively experienced discriminative stimuli. I. The fentanyl cue, a tool to investigate subjectively experience narcotic drug actions.
Fentanyl is reported to produce a discriminative stimulus that can control food-reinforced lever pressing in rats that is generalized with fentanyl injection, whereas the neuroleptic haloperidol is not. Expand
Behavioral and electrographic changes in rat and man after MSH.
Publisher Summary This chapter focuses on the two-fold approach related to the actions of melanocyte-stimulating hormone (MSH) on the central nervous system (CNS): first, to determine whether MSH hasExpand
Effects of adrenocorticotropic hormone on avoidance behaviour of intact and adrenalectomized rats.
Improvement of avoidance acquisition by a single injection of ACTH was found in the early phase of conditioning in intact and adrenalectomized rats treated with short-acting ACTH for 14 days. Expand
Interaction between ACTH fragments, brain opiate receptors and morphine-induced analgesia.
It is confirmed that N-terminal fragments of ACTH have an affinity for rat brain opiate receptors in vitro and the structure-activity relationship for these two parameters is comparable to that observed for the same peptides on the induction of excessive grooming. Expand
Adrenocortical activity and avoidance learning as a function of time after avoidance training
Abstract Shuttlebox avoidance learning in rats is a U-shaped function of time after original avoidance training. The descending limb of the function is correlated with a decrease in plasmaExpand
Narcotic cue and narcotic state.
The purpose of the present review is to analyze the available literature data on stimulus control by narcotic analgesic drugs, and to discuss some of the conclusions reached thus far. Expand