Selective interaction of lansoprazole and astemizole with tau polymers: potential new clinical use in diagnosis of Alzheimer's disease.

@article{Rojo2010SelectiveIO,
  title={Selective interaction of lansoprazole and astemizole with tau polymers: potential new clinical use in diagnosis of Alzheimer's disease.},
  author={Leonel E. Rojo and Jans H. Alzate-Morales and Iv{\'a}n N Saavedra and Peter Davies and Ricardo Benjamin Maccioni},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={19 2},
  pages={573-89}
}
We describe the interactions of two benzimidazole derivatives, astemizole (AST) and lansoprazole (LNS), with anomalous aggregates of tau protein (neurofibrillary tangles). Interestingly, these compounds, with important medical applications in the treatment of allergies and gastrointestinal disorders respectively, specifically bind to aggregated variants of tau protein and to paired helical filaments isolated from brains of Alzheimer's disease (AD) patients. These ligands appear to be a powerful… CONTINUE READING
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