Selective inner hair cell loss does not alter distortion product otoacoustic emissions

@article{Trautwein1996SelectiveIH,
  title={Selective inner hair cell loss does not alter distortion product otoacoustic emissions},
  author={Patricia Trautwein and Peter Hofstetter and Jian Wang and R. Salvi and A. Nostrant},
  journal={Hearing Research},
  year={1996},
  volume={96},
  pages={71-82}
}
Outer hair cells (OHC) are believed to be the dominant source of distortion product otoacoustic emissions (DPOAE) in mammals; however, some studies in genetic mutants suggest that inner hair cell (IHC) loss may lead to a significant reduction of DPOAE amplitude. In the present study, we determined the extent to which IHC loss altered DPOAE amplitude by using carboplatin to destroy selectively the IHCs in the chinchilla while sparing virtually all of the OHCs. IHC losses of 80-100% with normal… CONTINUE READING

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