Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk.

Abstract

The effect of selective injury to dopaminergic neurons on the expression of glial cell line-derived neurotrophic factor (GDNF) was examined in substantia nigra cell cultures. H(2)O(2), mimicking increased oxidative stress, or l-DOPA, the main symptomatic treatment for Parkinson's disease, increased GDNF mRNA and protein levels in a time-dependent mode in… (More)

Topics

Cite this paper

@article{Saavedra2006SelectiveIT, title={Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk.}, author={Ana Saavedra and Graça Baltazar and Paulo de Andrade Santos and Caetana Monteiro Carvalho and Em{\'i}lia Pedrosa Duarte}, journal={Neurobiology of disease}, year={2006}, volume={23 3}, pages={533-42} }