Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester.

@article{Grey1994SelectiveIE,
  title={Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester.},
  author={Shane T. Grey and Akihiko Tsuchida and Harald Hau and C L Orthner and Hatem H. Salem and Wayne W Hancock},
  journal={Journal of immunology},
  year={1994},
  volume={153 8},
  pages={3664-72}
}
Recent studies have shown that infusion of the anticoagulant protein, activated protein C (APC), can ameliorate many of the systemic effects of endotoxemia in experimental animals, although the mechanisms in this action are unknown. We investigated the effects of APC on the responses of blood monocytes, alveolar macrophages, and cells of the monocyte line, THP-1, to stimulation in vitro by LPS, IFN-gamma, or PMA. Mononuclear phagocyte (MO) activation was associated with rapid production of TNF… CONTINUE READING

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