Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors.

  title={Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors.},
  author={Kouichiro Goto and Yuto Kamiya and Takeshi Imamura and Kohei Miyazono and Keiji Miyazawa},
  journal={The Journal of biological chemistry},
  volume={282 28},
The inhibitory Smads, Smad6 and Smad7, play pivotal roles in negative regulation of transforming growth factor-beta (TGF-beta) family signaling as feedback molecules as well as mediators of cross-talk with other signaling pathways. Whereas Smad7 acts as a ubiquitous inhibitor of Smad signaling, Smad6 has been shown to effectively inhibit bone morphogenetic protein (BMP) signaling but only weakly TGF-beta/activin signaling. In the present study, we have found that Smad6 inhibits signaling from… CONTINUE READING


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