Selective inhibitors of butyrylcholinesterase: a valid alternative for therapy of Alzheimer's disease?

@article{Giacobini2001SelectiveIO,
  title={Selective inhibitors of butyrylcholinesterase: a valid alternative for therapy of Alzheimer's disease?},
  author={Ezio Giacobini},
  journal={Drugs & aging},
  year={2001},
  volume={18 12},
  pages={891-8}
}
The brain of mammals contains two major forms of cholinesterases (ChEs): acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ genetically, structurally and in their kinetics. Butyrylcholine is not a physiological substrate in mammalian brains which makes the function of BuChE difficult to interpret. In human brains, BuChE is… CONTINUE READING