Selective inhibitor of slow reacting substance of anaphylaxis.

@article{Augstein1973SelectiveIO,
  title={Selective inhibitor of slow reacting substance of anaphylaxis.},
  author={Joachim Augstein and John Bates Farmer and Tongwon Lee and Philip Sheard and Mhn Tattersall},
  journal={Nature: New biology},
  year={1973},
  volume={245 146},
  pages={
          215-7
        }
}
IN the guinea-pig, anaphylaxis in the lung leads to the release of slow reacting substance of anaphylaxis (SRS-A) and histamine. Because the bronchoconstriction which accompanies anaphylaxis is greatly reduced by antihistamine drugs, histamine is thought to be the more important physiological mediator. But anaphylaxis induced in the human lung by antigen challenge and measured by alterations in the forced expiratory volume is only marginally reduced by antihistamine drugs1. Studies in vitro on… CONTINUE READING

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