Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model

@inproceedings{Tokunaga2017SelectiveIO,
  title={Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model},
  author={Yuko Tokunaga and Yosuke Osawa and Takahiro Ohtsuki and Yukiko K. Hayashi and Kenzaburo Yamaji and Daisuke Yamane and Mitsuko Hara and Keisuke Munekata and Kyoko Tsukiyama-Kohara and Tsunekazu Hishima and Soichi Kojima and Kiminori Kimura and Michinori Kohara},
  booktitle={Scientific Reports},
  year={2017}
}
Chronic hepatitis C virus (HCV) infection is one of the major causes of serious liver diseases, including liver cirrhosis. There are no anti-fibrotic drugs with efficacy against liver cirrhosis. Wnt/β-catenin signaling has been implicated in the pathogenesis of a variety of tissue fibrosis. In the present study, we investigated the effects of a β-catenin… CONTINUE READING